A case conceptualization tool

The Treatment Target Identification Model

A unifying map for clinicians: instead of inventing new therapies, the TTIM helps you find what is missing in a person's life for a good lived experience — and which evidence-based targets to treat.

✦ Five interconnected pillars ◆ 29 treatment targets

Proposed by Alexey Breuss, Psy.D.

The full Treatment Target Identification Model diagram
The complete TTIM — five pillars, treatment targets, and the systems beneath a lived experience
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01 — The paradox

Our therapies work. So why do so many people stay stuck?

Mental health interventions show consistent, moderate benefit — yet distress keeps rising and relapse is common. The TTIM proposes that our interventions don't need an overhaul. What needs refining is which targets we choose, and how we conceptualize them.

~⅓

of people who begin therapy end treatment without reliable improvement.

~6%

deteriorate over the course of treatment despite our best evidence-based care.

≈0

truly new mechanisms — most modalities re-articulate the same enduring human processes.

"The interventions we have don't need further editing — instead, treatment-target selection and better case conceptualization warrant refinement."

02 — What the TTIM is

One framework, beneath every modality

The TTIM is a visual, mechanism-oriented tool for case conceptualization. It is built to be used three ways — in education, in supervision, and in individual case formulation — and it deliberately targets "poor lived experience," not just diagnosable pathology.

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Targets for treatment, more than symptoms for management

The TTIM grounds intervention selection in established biological and psychological mechanisms, rather than chasing isolated symptoms or single diagnoses.

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A shared language

The TTIM bridges psychological and biological conceptualizations, giving medical and mental-health providers a common map they can both read.

Easy to use, iterative, and adaptable clinical tool

Training in guiding questions can surface targets quickly, the formulation evolves as therapy unfolds, and the model expands as the evidence base does.

A note on "lived experience"

The TTIM defines lived experience as a firsthand, subjective, personal experience of/reaction to one's environment. This deliberately includes people who present for therapy not because of their own pathology, but because of distress in those around them, or because they are navigating disempowering systems and hard conditions — while still retaining assessment for psychological pathology.

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Culture is a foundational aspect of the model

A framework grounded in cross-cultural science

The Theory of Constructed Emotion at the heart of the TTIM draws on research spanning diverse global populations — from Western to indigenous peoples — which shows that emotions are not universal but vary with culture, language, and context. Because of that foundation, the TTIM treats culture as a required step in every formulation rather than an afterthought. It helps clinicians distinguish what is innate human biology from what is culturally shaped, supports care when client and clinician share little common life experience, and is designed to act as a protective tool for clients who are culturally different or marginalized.

03 — The engine underneath

Emotion is constructed — and so is suffering

The TTIM is built on the Theory of Constructed Emotion and the biology of allostasis: the brain's constant prediction of the body's needs. Emotions emerge as the brain interprets bodily affect through learned concepts. When that predictive process goes awry, distress follows.

Theory of Constructed Emotion
Affect
Allostatic Load
Bodily feeling — valence & arousal — from running allostasis
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Concept
Cognitions
Learned categories: beliefs, language, schemas, experience
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Construction
Emotion
Meaning & an action urge, played out as behavior

In the full model, Affect and Concept grow into two of the pillars — Allostatic Load and Cognitions — joined because together they produce an emotional experience.

Inside the Skin

Metabolic Health shapes the Greater Nervous System, which produces Emotion (Affect + Concept). Executive Functioning gets special attention for its power to act on concept over raw affect.

Outside the Skin

The Greater World, Culture, Relationships and Behavior bidirectionally shape — and are shaped by — what happens inside. Biology and environment are inseparable from lived experience.

04 — The five pillars

Five things a good life is built on

Each pillar is a domain that must be maintained for positive mental health and a good lived experience. They are heavily interconnected — a deficit in one ripples through the others.

Tap any pillar to jump into the interactive explorer ↓

05 — Interactive explorer

Open the model up

Choose a pillar, then select any treatment target to see its rationale, the guiding questions a clinician can ask, and sample evidence-based interventions.

Select a treatment target to explore its questions and interventions.
Drag to pan · use + / − to zoom
The complete TTIM diagram
06 — In practice

How the TTIM works in the room

The model is meant to be used as a living cycle — surfacing targets, sharing them with the client, and planning collaboratively as the picture evolves.

1

Assess & formulate

Use the guiding questions during intake. Each flagged target invites deeper evaluation, building an idiographic picture of which pillars are in deficit.

2

Share & educate

Show the client the pillars and targets in deficit. Matter-of-fact psychoeducation reduces judgment, builds alliance, fosters hope, and is itself an intervention.

3

Plan & prioritize

Choose targets collaboratively. The most destabilizing ones (often Allostatic Load) come first. Re-prioritize as new data arrives — the cycle repeats.

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Guiding logic of the TTIM: The dose determines the poison — too much, or too little

The TTIM never claims a single factor predicts all outcomes. Instead it asks where internal and external factors sit in excess or deficit, and how those imbalances ripple through a life — an idea echoed in traditional models of restoring balance and research on trauma and resilience.

A cross-cutting consideration: Executive Functioning

Executive functioning isn't a pillar — you don't need it to feel positive emotion — but it influences nearly every outcome and every session. The model keeps it visible as a consideration across all targets (e.g., CBT for ADHD, environmental structuring, bottom-up regulatory strategies). Modern research does not support the idea that interventions targetting executive functioning have long-term effects, and instead, executive functioning can be scaffolded as a part of treatment. Guiding question: Does the client experience executive functioning deficits? (e.g., use an existing tool such as the BRIEF2.)

Adaptable by design

Built to be flexing depending on practical settings — and to grow

The TTIM is not static. It is built to adapt to different practice environments and acuity levels, and to let clinicians add, move, or remove treatment targets wherever a need arises — placing each one where it belongs in the model. As new research and modalities emerge, the framework expands with them.

New biologyDrop a specific peptide or hormone target into Metabolic Health, the Greater Nervous System, or Allostatic Load for higher-acuity and psychiatric work.
Genetic influenceAdd a “Genes” category under Inside the Skin (e.g., ADHD, autism, bipolar, alexithymia) when genetic factors shape the picture. Can be helpful for education or epigenetic work.
Community practiceAdd Greater World and Culture targets for clinicians, sociologists, anthropologists, and activists working beyond the individual.
Executive-function focusExpand into sub-targets — inhibition, working memory, shifting, planning, self-monitoring — for ADHD or BPD work.